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Maxis once again lets you play God-- but in contrast to SimEarth's macro-management, Simlife lets you design and manipulate the genes of plants and animals to see how they behave in a simulated environment. You can manipulate many aspects of the world, such as water/land ratio, yearly temperature cycles, moisture, soil depth, and more. Simlife is a great game for anyone with a passing interest in genetics and ecology. The downside was that the game was a memory hog for its time-- requiring a whopping 4MB to run If you like to tinker with genetics, SimLife is one of the best electronic "toys" of its kind. Highly recommended!
Note: this download is the rarer Windows version that works well on Windows 95 and above :)
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SimLife for Windows screenshot
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SimEarth, Sim Ant, SimIsle for Windows 95, SimFarm for Windows, SimTower